Taking Hemp to the Molecular Level

Hemp is not user friendly

Within the hemp plant there are in excess of 475 distinct compounds.

Nanologics_MolecularLevel

Greater than 80 have been identified as phytohemp.

Hemp derivatives inclusive of terpenes produce an "entourage effect." wherein they work together to enhance bioavailability. Their relative concentrations depend on a number of factors including hemp strain, plant genetics, soil climate conditions, cultivation techniques and most critically, the extraction technology for producing hemp concentrates.

Cannabinoids, like all oils, are poorly soluble in water. Through our technology, cannabinoid molecules become water compatible, thus rendering the highest bioavailability possible.

Limitations of Current Methods of Use

Current Delivery Methods (Titration) of Hemp Products Include:

  • Inhalation -- Smoking or vaporization
  • Oral -- Edibles, extract oils, tinctures, soft gel caps, drinks, tablets, lozenges and gum.
  • Intra-oral -- Sprays, tinctures, extracts, and emulsion compositions and hemp-containing chewing gums

Each of the Delivery Methods above have unique challenges.

Inhalation Delivery Methods Limitations

Smoking and vaporization cannot be dosed accurately.

  • Cellular absorption following smoking and vaporization was reported to be between 2% - 56% bio-availablity,
  • Bioavailability varies according to depth of inhalation, duration and breath retention.
  • About 30% of the THC present in a hemp cigarette is destroyed at combustion.
  • Vaporization is preferred to smoking however retains the same dosing challenges
Nanologics_thc

Intra-Oral Delivery Methods Limitations

Intra-Oral delivery methods of hemp:

  • Sprays (similar to Sativex)
  • Tinctures (a drop under the tongue)
  • Trokies (in the buckle of your teeth)

These delivery systems are further enhanced through nano technology. 

Oral Delivery Methods
Limitations

Oral delivery methods through infused edibles, beverages and ingested medicine.

  • Oral absorption of THC is slow and unpredictable, with peak blood concentrations occurring 1-5 hours after ingestion.
  • Psychotropic effects after oral use have been shown to set in after 30-90 minutes, peak between 2 to 4 hours, and decline to low levels after 6 hours.
  • The oral absorption of THC and Hemp are typically reported as 6% bioavailability (4%-12%) to the systemic circulation.
  • Initial degradation of THC is caused by digestive acids in the stomach and intestine. Extensive first-pass liver metabolism further reduces oral bioavailability of THC before it reaches the targets of delivery.
  • The hydroxylation of ingested THC in the liver to 11-hydroxy-THC creates significantly higher levels of this metabolite compared with inhalation that produces stronger psychotropic effects and greater tendency for adverse effects without warning.
NanoBiologics_Logo

NanoBiologics
Research Corporation

(951) 290-0298